EHDs meet the retromer
نویسندگان
چکیده
منابع مشابه
EHDs meet the retromer
Retrograde trafficking mediates the transport of endocytic membranes from endosomes to the trans-Golgi network (TGN). Dysregulation of these pathways can result in multiple ailments, including late-onset Alzheimer disease. One of the key retrograde transport regulators, the retromer complex, is tightly controlled by many factors, including the C-terminal Eps15 homology domain (EHD) proteins. Th...
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Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting s...
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ژورنال
عنوان ژورنال: Cellular Logistics
سال: 2012
ISSN: 2159-2799
DOI: 10.4161/cl.20582